Bioactive Small Molecules
Medchemexpress LLC Ephrin-B1/EFNB1 Mou 50ug
Ephrin-B1 (EFNB1) protein binds to Eph family receptors enabling signaling between receptor-expressing cells and cells with EFNB1 It is crucial for neuronal axon growth and expressed in various tissues like the adult lung and colon highlighting its widespread presence and importance in mediating cellular interactions Ephrin-B1/EFNB1 Protein Mouse (HEK293 Fc) is the recombinant mouse-derived Ephrin-B1/EFNB1 protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC SB 239063 | 193551-21-2 | 99.2% | 368.40 | 1 ML
SB 239063 is a potent, selective and orally active p38 MAPK inhibitor. It exhibits an IC50 of 44 nM for recombinant purified human p38α, with equipotent inhibitory activity against p38α and p38β. SB 239063 has no effect on p38γ or p38δ.
- Potent, selective, and orally active p38 MAPK inhibitor.
- Exhibits equipotent inhibitory activity against p38α and p38β.
- Has anti-asthma activity.
- Can enhance memory impaired due to aging or medical conditions, such as AD.
- Able to penetrate the blood brain barrier (BBB).
Cayman Chemical ANTIBODY SA 4503 50mg
A selective σ1 receptor agonist (Kis = 4.6 and 63 nM for σ1 and σ2, respectively); reduces light-induced cell death, decreases in σ1 expression, disruption of the mitochondrial membrane potential, and activation of caspase-3/7 in murine 661W cells at 10 μM; increases extracellular acetylcholine concentrations in the frontal cortex and improves step-through latency in a passive avoidance test in rats with scopolamine-induced memory impairment at 10 mg/kg; reduces working and reference memory errors induced by a time delay and MK-801 in a radial arm maze in rats at 0.3 mg/kg; pre-administration into the intravitreal space reduces light-induced thinning of the mouse retina outer nuclear layer at 500 μM
Medchemexpress LLC Meldonium dihydrate | 86426-17-7 | MFCD13461779 | 99.0% | 25 MG
Meldonium (MET-88) dihydrate functions as a cardioprotective agent by competitively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). It exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor.
- Functions as a cardioprotective agent
- Competitively inhibits γ-butyrobetaine hydroxylase (BBOX)
- Competitively inhibits carnitine/organic cation transporter type 2 (OCTN2)
- Exhibits IC50 values of 34-62 μM for human recombinant BBOX
- Shows an EC50 of 21 μM for human OCTN2
- Identified as a fatty acid oxidation inhibitor
Medchemexpress LLC Cyclopenthiazide | 742-20-1 | 98.4% | 379.88 | 100 MG
Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. It functions by inhibiting the reabsorption of sodium chloride and water in the distal renal tubules, thereby increasing the excretory capacity of the rat kidney.
- Functions as a benzothiadiazine diuretic.
- Possesses antihypertensive properties.
- Inhibits the reabsorption of sodium chloride and water at the distal renal tubules.
- Increases the excretory capacity of the rat kidney.
Medchemexpress LLC Unc 0631 | 1320288-19-4 | 99.3% | C37H61N7O2 | 10MG
UNC 0631 is a potent, research-grade inhibitor of the histone methyltransferase G9a. It inhibits G9a enzymatic activity (biochemical IC50 = 4 nM) and reduces H3K9me2 levels in multiple cell lines at low nanomolar concentrations, making it useful for epigenetics and chromatin-modification research.
- Potent G9a inhibition (biochemical IC50 = 4 nM).
- Effective cellular reduction of H3K9me2 at low nanomolar concentrations (examples: MCF7 18 nM; MDA-MB-231 25 nM).
- High purity for analytical applications (99.3%).
- Stable solid with recommended storage: powder -20°C for long term, 4°C for short term.
- Supplied as a light yellow crystalline solid suitable for research use.
- Suitable for studies of chromatin modification and epigenetic regulation.
Selleck Chemical LLC Ozanimod hydrochloride E4956-5MG
Ozanimod hydrochloride(Zeposia RPC-1063 HCL) is a potent sphingosine 1-phosphate (S1P)receptor modulator and a selective agonist of S1P receptor subtypes 1 (S1P1) and 5 (S1P5) with EC50 s of 1 03 nM and 8 6 nM respectively It can be used in the trearment of relapsing multiple sclerosis (MS)
Selleck Chemical LLC MTX-531 E4680-100MG
MTX-531(NSC827271) is a first-in-class potent and selective inhibitor of EGFR and PI3K with an IC50 of 14 7 nM and 6 4 nM respectively It may play a role in treating Head and Neck Squamous Cell Carcinoma (HSNCC) squamous lung cancers and certain EGFR/PI3K-driven triple-negative breast cancers
Medchemexpress LLC 4-methoxyphenyl 2-(4-(3,4,5-trimethoxybenzyl)piperazin-1-yl)acetate | 113594-64-2 | MFCD00874940 | 99.0% | 430.49 | C23H30N2O6 | 10 MG
KB-5492 free base is a small-molecule research compound that functions as a potent and selective sigma receptor inhibitor (IC50 = 3.15 μM) and has reported anti-ulcer activity. It is supplied as a solid (white to off-white) and as a 10 mM solution in DMSO for assay use.
- Potent sigma receptor inhibitor (IC50 = 3.15 μM).
- High purity, 99.0%.
- White to off-white solid appearance.
- Available in milligram quantities and as a DMSO solution.
- Suitable for in vitro pharmacology and mechanism-of-action studies.
Selleck Chemical LLC Semen Canavaliae Extract E3142-5MG
Semen Canavaliae Extract is extracted from Canavalia Gladiate which is a natural antioxidant and antibacterial agent with potential health benefits as well as application in the food industry
Cayman Chemical ANTIBODY CelocIdIn 5mg
An antibiotic; active against various bacterial strains, including M. tuberculosis, and trypanosomes; inhibits proliferation of EBV-transformed cells, activates the c-Myc and NF-κB pathways in vitro, and induces necrotic cell death in gammaherpes virus-infected B cells; protective against bacterial leaf blight in rice plants (100-200 ppm); inhibits α-ketoglutarate in X. oryzae (1 ppm)
Apexbio Technology LLC LY2603618, 10mM (in 1mL DMSO) CAS# 911222-45-2
LY2603618 is a novel small molecular checkpoint kinase 1 (Chk1) inhibitor that has direct anti-tumour effect [1], as well as desensitizing tumour cell against DNA-damaging chemotherapy treatment [2].Checkpoint kinase 1 (Chk1) is a type of kinase that coordinates damaged-DNA repair [1]. Some tumour cells have been found to possess over-regulated populations of Chk1 that desensitize the cell from DNA-targeting chemotherapy, promoting tumour proliferation [3].LY2603618 inhibits Chk1 by competing with ATP molecules [2]. In A549 and H1299 non-small cancer cell lines, lethal concentration of LY2603618 (10 M) not only resulted in cell proliferation arrest (increase population of cell at G2/M phase from 13% to 38%) but also directly DNA damage, the latter of which was indicated by the increasing occurrence of H2AX phosphorylation[1]. Other sizes are also available. Please inqury us for quote.
TARGETMOL CHEMICALS INC AMPA RECEPTOR ANTAGONIST 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AMPA receptor antagonist-3 is an AMPA receptor antagonist (patent US20070027143A1). purity: 98%
Selleck Chemical LLC Protease Inhibitor Library L2500-2X100UL/WELL
A unique collection of 454 small molecule inhibitors used for chemical genomics high-throughput screening (HTS) and high content screening (HCS)
Selleck Chemical LLC Lodoxamide E4875-1G
Lodoxamide (U-42585E free acid) is a potent agonist of GPR35 with an EC50 of 1 nM It also inhibits eosinophil peroxidase release after IgA activation and reduces eosinophil cationic protein and eosinophil-derived neurotoxin suggesting direct effects on eosinophils It is a mast cell stabilizer used to treat asthma allergic conjunctivitis and superior limbic keratoconjunctivitis